The third course on Practical Personalized Medicine

The third course on Practical Personalized Medicine

April 23 2017, the third course on Practical Personalized Medicine of the Competence Center of Personalized Medicine was held at the University Hospital Zurich. Students were very interactive and interested, thank you for the participation.

As in the years before, the dermatologist Alexander Navarini introduced the field of personalized medicine, the use of biomarkers for simple and complex stratification with machine learning, and the 4Ps, namely predictive, preventive, personalized and participatory medicine. Focusing on his field dermatology, he illustrated the power of stratification techniques in advanced melanoma and the use of clinical and visual data as biomarkers in inflammatory dermatoses.

Prof. Brigitte Tag, the chair of medical law and dean of the law faculty, introduced the students to legal considerations in personalized medicine. She highlighted important changes in the doctor-patient relationship as a consequence of 4P medicine, as well as as yet open questions of property of genetic data, the right not to know medically relevant data, and illustrated the relevant challenges for society as a whole.

The medical ethics specialist Dr. Alessandro Blasimme gave us a a modern perspective on app-based big data and ethical aspects of data collection and use.

Dr. Alexandre Theocharides demonstrated ground-breaking changes in personalized hematology and showed the increasing prevalence of several conditions due to highly efficacious strategies to control disease.

The cardiologist Andreas Flammer talked about personalized risk calculations for cardiovascular events and that medium-risk patients are the hardest to evaluate with these algorithms. New, early changes like endothelial function could add value to these efforts.

The internal medicine specialist Edouard Battegay gave a fascinating talk on cluster analysis of medical data and new associations that help us understand polymorbidity.

The metabolic disease specialist Matthias Baumgartner showed new investigative approaches for extremely rare disorders such as methylmalonic acidemia ,and a mouse model that allowed him to test new, recently identified potential treatments.

Our medical geneticist Anita Rauch demonstrated fascinating case studies from her practice, introduced students to interpret genetic changes and showed that there is more to modern genetics than whole exome sequencing and that clinical features are crucially important for a diagnosis.

The telemedicine specialist Martin Denz demonstrated the power of mobile device-derived biomarkers and that health data is collected and used ubiquitously, empowering both healthcare providers and patients.

Dr. D. Coman Schmid of ETH Zurich introduced students to the world of medical data handling, demonstrated strategies to manage big data and indicated secure ways to go about analysing medical data – a fascinating and very rewarding talk!

Finally, Prof. Onur Boyman showed personalized approaches to immunology and inspired students to think critically and search for new ways to improve medicine!

At the end of a long day that seemed way too short, the director of research and education of the University Hospital Zurich Prof. Gabriela Senti prepared a personal certificate to all participants that Alexandra Buender from the CC-PM distrubuted.

We thank the directorate of teaching and research of the University Hospital of Zurich, namely Prof. Gabriela Senti, for the ongoing support of our course!